A 29-year-old woman with mild persistent asthma presents with acute-onset bronchospasm, nasal congestion, and urticaria 30 minutes after taking ibuprofen for menstrual cramps. Vital signs: BP 128/82, HR 112, RR 24, SpO2 92% on room air. Chest examination reveals diffuse wheezing. Peak flow is 65% of predicted. She denies fever and has no prior anaphylaxis. Which medication is most appropriate for long-term prevention of similar episodes?
- A)MontelukastGABARITO
- B)Roflumilast
- C)Bosentan
- D)Theophylline
- E)N acetylcysteine
Explicação
Aspirin and other nonselective COX inhibitors can shunt arachidonic acid metabolism toward leukotriene production, worsening bronchoconstriction in susceptible patients. Montelukast blocks CysLT1 leukotriene receptors and is useful in aspirin induced asthma as... Ver explicação completa e trilha adaptativa →