A 28-year-old woman presents with a 6-month history of amenorrhea, tremor, heat intolerance, and palpitations. On examination, her thyroid is diffusely enlarged and nontender. Vital signs show resting heart rate of 98 bpm. Laboratory studies reveal: TSH: 0.2 mIU/L (normal 0.4-4.0) Free T4: 3.2 ng/dL (normal 0.8-1.8) Free T3: 8.5 pg/mL (normal 2.3-4.2) LH: 8 mIU/mL (normal follicular phase 1.9-12.5) FSH: 6 mIU/mL (normal follicular phase 3.1-8.7) Prolactin: 12 ng/mL (normal <25) Thyroid ultrasound demonstrates diffuse parenchymal enlargement with increased vascularity. Which of the following best explains the mechanism of amenorrhea in this patient?

1. A)Thyroid peroxidase antibodies directly attack ovarian tissue causing autoimmune destruction
2. B)Excess thyroid hormone increases the metabolic clearance of estrogen, resulting in decreased circulating estrogen levels
3. C)Thyroid hormone directly suppresses GnRH secretion from the hypothalamus, resulting in decreased LH and FSHGABARITO
4. D)TSH receptor antibodies cross-react with FSH receptors on ovarian granulosa cells
5. E)Excess thyroid hormone increases hepatic synthesis of sex hormone-binding globulin, reducing free estrogen bioavailability