A 30-year-old woman is brought to the emergency department because of severe headache and vomiting that started after she was hiking in the mountains at high altitude. She normally lives in a city that is close to sea level. Therapy is initiated with a drug that alkalinizes the urine. Which of the following is the most likely site of action of this drug in the kidney?
- A)Proximal convoluted tubuleGABARITO
- B)Ascending loop of Henle
- C)Glomerulus
- D)Collecting ducts
- E)Early distal convoluted tubule
Explicação
Acetazolamide, a carbonic anhydrase inhibitor, acts in the proximal convoluted tubule (PCT). It enhances bicarbonate elimination by blocking carbonic anhydrase, which normally catalyzes the conversion of CO2 and H2O to H2CO3 (and subsequently HCO3-). Bicarbona... Ver explicação completa e trilha adaptativa →