A 45-year-old man with alcohol use disorder presents with acute flushing, throbbing headache, nausea, palpitations, and diaphoresis 15 minutes after consuming one beer. Vital signs: BP 156/92 mmHg, HR 108 bpm, RR 18, temp 37.2°C. He denies chest pain or dyspnea. His medication list includes a recently initiated agent for alcohol cessation. Serum acetaldehyde level is elevated at 89 μmol/L. Inhibition of which enzyme most directly explains this disulfiram-like reaction?

1. A)Cytochrome oxidase
2. B)Aldehyde dehydrogenaseGABARITO
3. C)Xanthine oxidase
4. D)Alcohol dehydrogenase
5. E)Dihydrofolate reductase