A 52-year-old woman with rheumatoid arthritis (ESR 48 mm/h, CRP 12 mg/L) presenting with joint pain and morning stiffness is screened for a biologic therapy trial. She has no history of cardiac disease or diabetes. Patients with major comorbidities are excluded, medication adherence is monitored electronically, and outcomes are assessed at frequent protocolized visits by dedicated research staff. Which trial type is most consistent with this design?
- A)Explanatory efficacy trialGABARITO
- B)Case series
- C)Pragmatic trial
- D)Stepped wedge trial
- E)Cross sectional study
Explicação
Explanatory efficacy trials are designed to determine whether an intervention works under ideal, tightly controlled conditions. Strict eligibility criteria, intensive monitoring, and protocolized visits maximize internal validity. The goal is biologic efficacy... Ver explicação completa e trilha adaptativa →