A 40-year-old man is found unresponsive in his garage next to an open antifreeze container. He presents with BP 102/68, HR 118, RR 22, temperature 36.8°C, and SpO2 98% on room air. He has flank pain, confusion, and metabolic acidosis with serum osmolal gap of 18 mOsm/kg. Urinalysis reveals calcium oxalate crystals. He denies ingestion of ethanol or methanol. Which medication is most appropriate antidotal therapy?
- A)Atropine
- B)Protamine sulfate
- C)Dimercaprol
- D)N acetylcysteine
- E)FomepizoleGABARITO
Explicação
Ethylene glycol is metabolized by alcohol dehydrogenase to toxic acids, including oxalic acid, which contributes to renal injury and calcium oxalate crystal formation. Fomepizole blocks alcohol dehydrogenase and is the preferred antidote. Ver explicação completa e trilha adaptativa →