A 19 year old college student is evaluated after a routine laboratory panel shows total bilirubin of 2.5 mg/dL. He feels well but notes mild scleral icterus during exam week when he often skips meals. AST, ALT, alkaline phosphatase, CBC, and haptoglobin are all normal. Which of the following is the most likely explanation for his jaundice?
- A)Absent bilirubin UDP glucuronosyltransferase activity
- B)Complete obstruction of the common bile duct
- C)Defective canalicular transport of conjugated bilirubin
- D)Mildly decreased bilirubin UDP glucuronosyltransferase activityGABARITO
- E)Increased heme oxygenase activity in macrophages
Explicação
Gilbert syndrome is a benign condition caused by mildly reduced UDP glucuronosyltransferase activity. It leads to intermittent unconjugated hyperbilirubinemia triggered by fasting, stress, or illness in an otherwise healthy patient with normal liver enzymes an... Ver explicação completa e trilha adaptativa →