A 52-year-old man with COPD and hypertension started an antihypertensive medication one week ago. He now presents with a persistent, nonproductive cough that began three days after starting the new drug. Vital signs show BP 128/76 mmHg, HR 88 bpm, RR 20/min, and SpO2 98% on room air. Lung auscultation reveals clear breath sounds bilaterally without wheezing. Serum creatinine is 0.9 mg/dL, and serum potassium is 4.1 mEq/L. He denies dyspnea, chest pain, or fever. Angiotensin II levels are elevated despite excellent blood pressure control. Which drug class best explains this clinical presentation?
- A)Direct renin inhibitor
- B)Angiotensin II receptor blocker
- C)ACE inhibitorGABARITO
- D)Calcium channel blocker
- E)Alpha-1 blocker
Explicação
ACE inhibitors block the conversion of angiotensin I to angiotensin II, causing angiotensin II levels to remain low (not high). However, they increase bradykinin levels by inhibiting bradykinin breakdown, leading to a dry cough in 10-20% of patients. This is a... Ver explicação completa e trilha adaptativa →