A 34-year-old man presents with episodic dark urine in the morning and abdominal pain. He has a history of a hepatic vein thrombosis. Laboratory studies show hemolytic anemia with elevated lactate dehydrogenase. Flow cytometry demonstrates absent CD55 and CD59 on blood cells. Which of the following is the most likely diagnosis?
- A)Autoimmune hemolytic anemia
- B)G6PD deficiency
- C)Paroxysmal nocturnal hemoglobinuriaGABARITO
- D)Microangiopathic hemolytic anemia
- E)Hereditary spherocytosis
Explicação
Paroxysmal nocturnal hemoglobinuria is the correct answer because loss of CD55 and CD59 makes blood cells susceptible to complement-mediated lysis. Ver explicação completa e trilha adaptativa →