A 61-year-old groundskeeper with decades of pesticide exposure presents with progressive resting tremor, bradykinesia, and rigidity. Vital signs: BP 138/82, HR 62, RR 16, Temp 37°C, SpO2 98%. MRI shows preserved striatal volume without iron deposition. Serum copper and ceruloplasmin are normal. Research testing reveals selective inhibition of electron transfer from NADH to coenzyme Q in his dopaminergic neurons. Which mitochondrial component is most likely inhibited?
- A)Complex III
- B)Complex IGABARITO
- C)Complex IV
- D)ATP synthase
- E)Complex II
Explicação
Rotenone and MPP positive inhibit complex I, blocking electron transfer from NADH to coenzyme Q. Chronic exposure can produce parkinsonian features by damaging dopaminergic neurons. The mechanistic description in the stem directly localizes the lesion to NADH ... Ver explicação completa e trilha adaptativa →