A 34-year-old woman arrives at the emergency department with somnolence after ingesting excessive diazepam. Vital signs show BP 118/76, HR 88, RR 10, temperature 37°C, and SpO2 98% on room air. Physical examination reveals normal pupils, no focal neurologic deficits, and intact gag reflex. Serum benzodiazepine level is elevated at 850 ng/mL. The team considers administering flumazenil as an antidote. Which mechanism best describes flumazenil's action?
- A)Stimulation of mu opioid receptors
- B)Irreversible inhibition of monoamine oxidase
- C)Inhibition of alcohol dehydrogenase
- D)Blockade of N methyl D aspartate receptors
- E)Competitive antagonism at the benzodiazepine binding site on the GABA A receptorGABARITO
Explicação
Flumazenil is a competitive antagonist at the benzodiazepine site on the GABA A receptor. It can reverse benzodiazepine induced sedation, although it must be used cautiously because it can precipitate seizures in selected patients. Ver explicação completa e trilha adaptativa →