A 74-year-old man is brought to the intensive care unit following emergency exploratory laparotomy for perforated diverticulitis with fecal peritonitis. He has a history of hypertension and type 2 diabetes mellitus. Despite receiving 3 liters of intravenous crystalloid resuscitation over the past two hours, he remains hemodynamically unstable. His temperature is 39.4°C, heart rate is 118 beats per minute, respiratory rate is 24 breaths per minute, and mean arterial pressure is 52 mm Hg. Laboratory studies reveal a lactate of 4.8 mmol/L, white blood cell count of 22,000/µL, and creatinine of 2.1 mg/dL. Physical examination demonstrates warm, flushed extremities with bounding pulses consistent with distributive shock physiology. A vasopressor is chosen that increases vascular tone predominantly through alpha-1 adrenergic receptor stimulation while also supporting cardiac contractility through beta-1 adrenergic receptor stimulation. Which of the following agents is most appropriate?

  1. A)Isoproterenol
  2. B)Dobutamine
  3. C)Nitroglycerin
  4. D)Milrinone
  5. E)NorepinephrineGABARITO

Explicação

Norepinephrine is the first line vasopressor for septic shock because its strong alpha 1 effects increase systemic vascular resistance and blood pressure, while beta 1 activity helps support cardiac output. This fits persistent vasodilatory shock after fluids. Ver explicação completa e trilha adaptativa →

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