A 49-year-old man with Parkinson disease controlled on selegiline presents with fever (38.9°C), agitation, diarrhea, and inducible ankle clonus after starting sertraline for depression. Vital signs show tachycardia (102 bpm) and tachypnea (20 breaths/min). Laboratory studies reveal elevated creatine kinase (1,200 U/L). He denies recent infections or medication non-adherence. Which of the following best explains this drug interaction?

1. A)Wilson disease unmasked by serotonergic therapy
2. B)Serotonin syndrome precipitated by MAO-B inhibition and SSRI useGABARITO
3. C)Acute dystonia due to D2 blockade in the nigrostriatal pathway
4. D)Neuroleptic malignant syndrome due to dopamine depletion
5. E)Combined cholinergic toxicity due to muscarinic excess