A 24-year-old laboratory worker is brought to the emergency department after sudden collapse during a chemical spill. He is tachypneic (RR 28/min) and confused. Vital signs show BP 102/68 mmHg, HR 118/min, temperature 37.2°C, and SpO2 98% on room air. Venous blood gas reveals elevated oxygen saturation with markedly elevated lactate (8.2 mmol/L). He denies chest pain. Which of the following components of oxidative phosphorylation is most likely inhibited?
- A)Complex IVGABARITO
- B)Complex II
- C)ATP synthase
- D)Complex I
- E)Complex III
Explicação
Cyanide inhibits cytochrome c oxidase, also known as complex IV of the electron transport chain. Cells cannot use oxygen, so venous blood remains unusually oxygen rich and anaerobic metabolism produces lactic acidosis. The combination of exposure, high lactate... Ver explicação completa e trilha adaptativa →