A 53-year-old man presents with a 6-month history of fatigue, chronic diarrhea, and 8-kg weight loss. He reports a recurrent blistering rash that appears in crops on his lower extremities, perineum, and around his mouth. The lesions progress through vesicular, pustular, and crusted stages before healing, leaving areas of bronze-colored induration. Vital signs are stable. Laboratory studies show: fasting glucose 236 mg/dL, hemoglobin 10.1 g/dL (MCV 85 fL), and a serum albumin of 3.2 g/dL. Abdominal ultrasound reveals a 3-cm solid mass in the pancreatic head. Which of the following cell types is most likely the origin of this neoplasm?
- A)Pancreatic acinar cells
- B)Pancreatic α-cellsGABARITO
- C)Pancreatic β-cells
- D)Pancreatic δ-cells
- E)Gastric G-cells
Explicação
This clinical presentation is classic for glucagonoma, a neuroendocrine tumor arising from pancreatic α-cells. The patient exhibits the pathognomonic triad of necrolytic migratory erythema (NME)—the blistering rash in various stages of healing with characteris... Ver explicação completa e trilha adaptativa →