A 45 year old man with a history of heavy alcohol use presents with severe epigastric pain radiating to the back and repeated vomiting. Serum lipase is markedly elevated. CT of the abdomen shows pancreatic inflammation and surrounding fat stranding. During surgery, the peripancreatic tissue contains chalky white deposits. Which of the following best explains this finding?
- A)Protein denaturation due to ischemia in a solid organ
- B)Immune complex mediated damage to vessel walls with plasma protein leakage
- C)Cell swelling due to failure of the sodium potassium ATPase pump
- D)Apoptotic cell death through caspase activation without inflammation
- E)Enzymatic destruction of fat with release of fatty acids that bind calciumGABARITO
Explicação
Acute pancreatitis releases lipases that digest peripancreatic adipose tissue, liberating free fatty acids that complex with calcium to form soaps. This enzymatic fat necrosis produces the characteristic chalky white deposits described in the vignette. Ver explicação completa e trilha adaptativa →