A 14 month old boy is evaluated for persistent fever and cervical lymphadenitis 6 weeks after receiving the BCG vaccine outside the United States. Culture of a lymph node aspirate grows an attenuated strain of Mycobacterium bovis. He has also had recurrent infections with nontuberculous mycobacteria. Flow cytometry shows normal T cell and B cell numbers. Which of the following immune defects best explains this patient's disease?

1. A)Impaired response of macrophages to interferon gammaGABARITO
2. B)Defective terminal complement activation
3. C)Failure of VDJ recombination in lymphoid precursors
4. D)Absent expression of CD40 ligand on T helper cells
5. E)Inability to form neutrophil extracellular traps