A 4-year-old girl develops bloody diarrhea after consuming undercooked beef at a picnic. Five days later, she presents with pallor and oliguria. Vital signs show BP 142/88 mmHg, HR 118/min, RR 22/min, and Temp 37.2°C. Laboratory studies reveal hemoglobin 7.2 g/dL with schistocytes on blood smear, platelets 45,000/μL, creatinine 2.8 mg/dL, and normal coagulation studies. Urinalysis shows no proteinuria. Which of the following is the most likely cause?
- A)Immune complex deposition after streptococcal infection
- B)Deficiency of ADAMTS13 metalloprotease
- C)Autoantibodies to glomerular basement membrane collagen
- D)Shiga like toxin mediated endothelial injuryGABARITO
- E)Severe vitamin K deficiency
Explicação
Hemolytic uremic syndrome classically follows infection with shiga toxin producing bacteria such as enterohemorrhagic E coli. Endothelial injury triggers microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Ver explicação completa e trilha adaptativa →