A 34-year-old woman with a history of major depressive disorder, currently maintained on sertraline 100 mg daily, presents to the emergency department several hours after developing a severe unilateral throbbing headache with photophobia and nausea. Unable to reach her physician, she took a medication from her friend's cabinet to treat what she believed was a migraine attack. On arrival, she is agitated and diaphoretic. Vital signs reveal a blood pressure of 148/92 mmHg, heart rate of 118 bpm, respiratory rate of 22 breaths per minute, and temperature of 39.4°C. Physical examination demonstrates bilateral hyperreflexia, inducible ankle clonus, and mydriasis. Which of the following medications most likely precipitated this syndrome?
- A)Scopolamine
- B)Diphenhydramine
- C)SumatriptanGABARITO
- D)Propranolol
- E)Lithium carbonate stopped 1 month ago
Explicação
Serotonin syndrome is characterized by mental status changes, autonomic instability, hyperthermia, and neuromuscular hyperactivity such as clonus and hyperreflexia. Combining an SSRI with another serotonergic drug such as sumatriptan can precipitate this toxic... Ver explicação completa e trilha adaptativa →