A 24 year old woman undergoes emergency delivery for placental abruption. Shortly afterward she develops diffuse oozing from venipuncture sites, hypotension, and hematuria. Laboratory studies show platelet count 28,000/mm3, prolonged PT, prolonged PTT, low fibrinogen, and markedly elevated D dimer. Which of the following mechanisms best explains this patient's condition?
- A)Reduced ADAMTS13 activity
- B)Autoimmune destruction of platelets only
- C)Widespread activation of coagulation with consumption of platelets and clotting factorsGABARITO
- D)Defective platelet glycoprotein IIb/IIIa
- E)Deficiency of factor VIII
Explicação
Disseminated intravascular coagulation is caused by widespread activation of coagulation, leading to diffuse fibrin deposition, microthrombi, and consumption of platelets and clotting factors. Obstetric catastrophes are classic triggers, and the combination of... Ver explicação completa e trilha adaptativa →