A 54-year-old man with 10-year history of hypertension and type 2 diabetes presents for research evaluation of endothelial dysfunction. Current medications include metformin and lisinopril. Vital signs show BP 158/92 mmHg, HR 78/min, RR 16/min, temp 37°C, SpO2 98% on room air. Laboratory studies reveal fasting glucose 156 mg/dL and elevated creatinine at 1.3 mg/dL. Vascular studies demonstrate reduced endothelial-derived vasodilator production synthesized from arginine. Which compound is significantly decreased?
- A)Serotonin
- B)Dopamine
- C)Nitric oxideGABARITO
- D)Histamine
- E)Melatonin
Explicação
Nitric oxide is synthesized from arginine by nitric oxide synthase in endothelial cells and diffuses into smooth muscle to increase cyclic GMP, causing vasodilation. Reduced nitric oxide bioavailability is a key feature of endothelial dysfunction in vascular d... Ver explicação completa e trilha adaptativa →