A 48-year-old woman presents with progressive pruritus and fatigue for 3 months. Vital signs: BP 118/76, HR 88, RR 16, Temp 98.6°F, SpO2 98% on room air. Laboratory studies reveal alkaline phosphatase 312 U/L, total cholesterol 284 mg/dL, and serum anti-mitochondrial antibodies positive. Liver biopsy demonstrates granulomatous inflammation of intrahepatic bile ducts. She denies recent alcohol use. Which of the following best describes the underlying pathologic lesion?
- A)Fibrosing inflammation of intrahepatic and extrahepatic bile ducts associated with ulcerative colitis
- B)Massive hepatocyte necrosis after acetaminophen overdose
- C)Autoimmune destruction of small intrahepatic bile ductsGABARITO
- D)Copper deposition due to ATP7B mutation
- E)Obstruction of the common bile duct by a pancreatic head mass
Explicação
Primary biliary cholangitis is an autoimmune cholestatic disease characterized by destruction of small intrahepatic bile ducts, leading to pruritus, elevated alkaline phosphatase, hypercholesterolemia, and anti-mitochondrial antibodies. It occurs classically i... Ver explicação completa e trilha adaptativa →