A 26-year-old woman at 8 weeks' gestation presents with thyroid tenderness, heat intolerance, and palpitations. Vital signs show BP 138/82 mmHg, HR 108/min, RR 18/min, and temperature 37.2°C. TSH is suppressed at 0.1 mIU/L with elevated free T4 of 2.8 ng/dL. Thyroid ultrasound demonstrates diffuse enlargement without nodules. She denies recent iodine exposure. Because of her pregnancy timing, her physician prescribes a thionamide that inhibits both thyroid peroxidase and peripheral T4-to-T3 conversion. Which drug was most likely prescribed?
- A)Radioactive iodine
- B)Propranolol
- C)PropylthiouracilGABARITO
- D)Methimazole
- E)Potassium iodide
Explicação
Propylthiouracil is preferred during the first trimester because methimazole is teratogenic. PTU also inhibits peripheral 5 prime deiodinase, so it decreases conversion of T4 to T3 in addition to blocking thyroid hormone synthesis. Ver explicação completa e trilha adaptativa →