A 31-year-old woman with Graves disease presents with fever (38.9°C), severe pharyngitis, and malaise 6 weeks after initiating antithyroid therapy. Vital signs show tachycardia (102/min) and tachypnea (18/min). Laboratory evaluation reveals marked neutropenia (WBC 1,200/μL with absolute neutrophil count 400/μL) and normal thyroid function tests. Pregnancy test is negative. She denies recent infections or other medications. Which antithyroid drug most likely caused this agranulocytosis?
- A)Desmopressin
- B)Radioactive iodine
- C)Propranolol
- D)MethimazoleGABARITO
- E)Levothyroxine
Explicação
Methimazole can cause agranulocytosis, a life threatening complication that often presents with fever and sore throat. In a nonpregnant patient it is commonly chosen over PTU because PTU carries greater hepatotoxic risk. Ver explicação completa e trilha adaptativa →