A 45-year-old woman with a 15-year history of primary biliary cholangitis presents with progressive fatigue, pruritus, and jaundice. Laboratory studies show elevated alkaline phosphatase and direct bilirubin, with positive antimitochondrial antibodies. She reports recent onset xanthomas on her elbows. Which of the following is the most appropriate initial pharmacologic management?
- A)Azathioprine
- B)Corticosteroids
- C)Ursodeoxycholic acidGABARITO
- D)Penicillamine
- E)Interferon-alpha
Explicação
Ursodeoxycholic acid is the standard initial therapy for primary biliary cholangitis, slowing disease progression and improving survival when started early. It reduces cholestasis and hepatic inflammation. Ver explicação completa e trilha adaptativa →