A 57-year-old woman with type 2 diabetes and hypertension is started on lisinopril 10 mg daily. Two weeks later, she presents with a persistent dry cough, dyspnea, and wheezing. Vital signs show BP 128/76 mmHg, HR 82, RR 22, temperature 37.2°C, and SpO2 98% on room air. Chest X-ray reveals no infiltrates or pulmonary edema. She denies fever, sputum production, or recent upper respiratory infection. Which mechanism best explains this adverse effect?
- A)Increased aldosterone secretion
- B)Enhanced prostaglandin degradation
- C)Direct beta 2 receptor stimulation
- D)Accumulation of bradykininGABARITO
- E)Blockade of sodium channels in airway nerves
Explicação
ACE inhibitors decrease conversion of angiotensin I to angiotensin II and also decrease breakdown of bradykinin. Accumulation of bradykinin contributes to the classic dry cough and, in some cases, angioedema. Ver explicação completa e trilha adaptativa →