A 58-year-old man with sepsis presents with acute kidney injury. Vital signs show BP 92/58 mmHg, HR 118/min, RR 22/min, temperature 39.2°C, and SpO2 98% on room air. Serum creatinine is 3.2 mg/dL (baseline 0.9 mg/dL). Urinalysis shows muddy brown casts without proteinuria. He denies recent nephrotoxin exposure. A researcher administers inulin, a substance freely filtered at the glomerulus that is neither reabsorbed nor secreted anywhere along the nephron. Clearance of this substance most accurately reflects which of the following?
- A)Filtration fraction
- B)Glomerular filtration rateGABARITO
- C)Urinary concentrating ability
- D)Effective renal blood flow
- E)Renal plasma flow
Explicação
Glomerular filtration rate is correct. A substance like inulin that is freely filtered and neither reabsorbed nor secreted has a clearance equal to the volume of plasma filtered per unit time. This makes it the gold standard conceptual marker for GFR. Ver explicação completa e trilha adaptativa →