A 51-year-old woman presents with a 2-week history of severe anxiety, palpitations, and tremor. She was started on amiodarone for atrial fibrillation 2 weeks ago. Vital signs show HR 108 bpm, BP 142/88 mmHg, RR 18, temperature 37.2°C. Laboratory studies reveal TSH 0.2 mIU/L (normal 0.4–4.0), free T4 2.1 ng/dL, and free T3 3.1 pg/mL. She denies recent weight loss. Which of the following best explains her presentation?
- A)Graves' disease triggered by amiodarone exposure
- B)Atrial fibrillation breakthrough with inadequate rate control
- C)Amiodarone-induced hypothyroidism from iodine excess
- D)Drug-induced lupus with thyroid involvement
- E)Amiodarone-induced type I thyroiditis with thyroid hormone releaseGABARITO
Explicação
Amiodarone contains high iodine content and can trigger destructive thyroiditis (type I amiodarone-induced thyroiditis) in patients with underlying thyroid disease or predisposition. This causes thyroid inflammation, release of preformed thyroid hormones into ... Ver explicação completa e trilha adaptativa →