A 28-year-old man presents with acute bilateral leg paralysis, urinary retention, and acute lower back pain following lower back sensory loss. Vital signs: BP 128/82 mmHg, HR 92/min, RR 16/min, temp 37.2°C, SpO2 98% on room air. MRI cervical and thoracic spine shows T2 hyperintensity spanning 3 thoracic vertebral segments; brain MRI is normal. CSF analysis reveals elevated protein. Which antibody is most likely positive?
- A)Anti-nuclear antibody (ANA)
- B)Anti-NMDA receptor
- C)Anti-aquaporin-4 (AQP4)GABARITO
- D)Anti-myelin oligodendrocyte glycoprotein (MOG)
- E)Anti-amphiphysin
Explicação
Longitudinally extensive transverse myelitis (LETM) with cord involvement spanning ≥3 segments, presenting with bilateral leg paralysis and urinary retention, is characteristic of neuromyelitis optica spectrum disorder (NMOSD). Anti-AQP4 antibodies are present... Ver explicação completa e trilha adaptativa →