A 46-year-old man with poorly controlled hypertension (BP 168/102 mmHg) reports progressive enlargement of his hands and feet requiring larger shoe sizes over 3 years, along with intermittent headaches. Examination reveals frontal bossing, prognathism, and coarse facial features. Laboratory studies show elevated insulin-like growth factor 1 (850 ng/mL; normal <200) and fasting glucose 128 mg/dL. Notably, no visual field defects are documented on screening. Which of the following is the best next diagnostic test to confirm the disorder?

  1. A)Oral glucose tolerance test showing failure of growth hormone suppressionGABARITO
  2. B)24-hour urine catecholamine measurement
  3. C)Low dose dexamethasone suppression test
  4. D)Water deprivation test
  5. E)ACTH stimulation test

Explicação

Acromegaly is usually caused by a GH secreting pituitary adenoma. Failure of GH suppression by oral glucose confirms the diagnosis. Ver explicação completa e trilha adaptativa →

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