A 57-year-old male with poorly controlled type 1 diabetes presents with progressive vision loss. Vitals: BP 148/92 mmHg, HR 88/min, RR 16/min, Temp 37.2°C. Ophthalmoscopic examination reveals macular edema, retinal thickening, and hard yellow-white lipid exudates. Laboratory studies show fasting glucose 285 mg/dL, triglycerides 380 mg/dL, and LDL cholesterol 165 mg/dL; urinalysis is negative for ketones. Which metabolic pathway abnormality in type 1 diabetes contributes most to this hyperlipidemia and retinal lipid deposition?

1. A)Glucose conversion to sorbitol in the lens
2. B)Overactive GLUT2 in liver
3. C)Overactive hormone-sensitive lipaseGABARITO
4. D)Overactive GLUT4 in adipose
5. E)Overactive lipoprotein lipase