A 26-year-old man presents with severe diffuse myalgias, abdominal cramping, and diaphoresis after sustaining a spider bite while cleaning a garage. Vital signs show BP 158/94 mmHg, HR 112 bpm, RR 18/min, and temp 37.2°C. Examination reveals generalized muscle rigidity and fasciculations. Serum creatine kinase is elevated at 890 U/L. There is no rash or neurologic deficit. Which toxin best explains these clinical findings?
- A)Autoimmune destruction of nicotinic receptors
- B)Blockade of voltage gated sodium channels in peripheral nerves
- C)Irreversible inhibition of acetylcholinesterase
- D)Inhibition of acetylcholine release at the neuromuscular junction
- E)Massive presynaptic release of acetylcholine and norepinephrineGABARITO
Explicação
Black widow spider venom contains alpha latrotoxin, which causes massive presynaptic neurotransmitter release, including acetylcholine and norepinephrine. This leads to painful muscle spasms, autonomic activation, and abdominal cramping. Ver explicação completa e trilha adaptativa →