A 65-year-old man with severe COPD taking theophylline presents with nausea, tremor, and insomnia. Vital signs show HR 128 bpm, BP 142/88 mmHg, RR 22, temperature 37.2°C, and SpO2 94% on room air. He started ciprofloxacin three days ago for prostatitis. ECG reveals supraventricular tachycardia. Serum theophylline level is 24 mcg/mL (therapeutic range 10-20). He denies chest pain or dyspnea worsening. Which drug interaction most likely explains his toxicity?
- A)Roflumilast
- B)Montelukast
- C)Tiotropium
- D)TheophyllineGABARITO
- E)Ipratropium
Explicação
Theophylline is a nonspecific phosphodiesterase inhibitor and adenosine receptor antagonist with a narrow therapeutic index. It can cause nausea, tremor, insomnia, and tachyarrhythmias, and its levels rise with drugs that reduce its metabolism, making toxicity... Ver explicação completa e trilha adaptativa →