A 59-year-old man with a history of hypertension and stable angina presents to clinic for medication adjustment. His current antihypertensive regimen includes lisinopril and hydrochlorothiazide, but his blood pressure remains at 138/88 mmHg and he continues to experience anginal episodes with exertion. Physical examination reveals BP 138/88 mmHg, HR 68 bpm, regular rhythm, no peripheral edema, and normal neurologic examination. Troponin is negative and ECG shows no acute ischemic changes. A calcium channel blocker is added to his regimen. One week later, the patient reports severe constipation that has required daily use of over-the-counter laxatives, but denies headaches, ankle swelling, or syncope. Which of the following calcium channel blockers was most likely prescribed?
- A)Amlodipine
- B)VerapamilGABARITO
- C)Diltiazem
- D)Nifedipine
- E)Felodipine
Explicação
Verapamil is a non-dihydropyridine calcium channel blocker with potent negative inotropic and chronotropic effects. Critically, verapamil significantly reduces gastrointestinal smooth muscle contractility by blocking L-type calcium channels in the GI tract, le... Ver explicação completa e trilha adaptativa →