A 52-year-old man with a 20-year history of alcohol use disorder presents to clinic with progressive abdominal distension and lower extremity edema. He reports fatigue and early satiety. On examination, he has hepatomegaly, ascites, and splenomegaly. Laboratory studies show AST 185 U/L, ALT 95 U/L, alkaline phosphatase 120 U/L, total bilirubin 2.1 mg/dL, and serum albumin 2.9 g/dL. Abdominal ultrasound reveals a cirrhotic liver with features of portal hypertension. A liver biopsy is performed and shows extensive fibrosis with regenerating hepatocyte nodules separated by fibrous septa. Immunohistochemistry demonstrates alpha-smooth muscle actin (α-SMA) positive cells within the fibrotic tissue. Which of the following cell types is primarily responsible for the excessive collagen deposition observed in this patient's liver?
- A)Hepatocytes undergoing epithelial-mesenchymal transition
- B)Kupffer cells producing transforming growth factor-beta
- C)Activated hepatic stellate cellsGABARITO
- D)Fibrocytes recruited from bone marrow
- E)Portal tract fibroblasts migrating into the lobule
Explicação
Hepatic stellate cells (HSCs) are the primary cell type responsible for hepatic fibrosis in chronic liver disease. In response to chronic alcohol-induced hepatocyte injury, HSCs become activated and transform into myofibroblasts (α-SMA positive), which produce... Ver explicação completa e trilha adaptativa →