A 46-year-old man presents to the emergency department 2 hours after ingesting windshield washer fluid. He is confused and reports blurred vision. Vital signs: BP 118/76 mmHg, HR 102/min, RR 22/min, temperature 37.2°C, SpO2 98% on room air. Laboratory studies show anion gap metabolic acidosis (pH 7.28, bicarbonate 16 mEq/L) with elevated osmolar gap of 18 mOsm/kg. Serum glucose is normal. Which of the following is the most appropriate antidotal therapy?
- A)N-acetylcysteine
- B)Hydroxocobalamin
- C)Methylene blue
- D)FomepizoleGABARITO
- E)Deferoxamine
Explicação
Methanol is metabolized by alcohol dehydrogenase to formic acid, which causes optic nerve toxicity and anion gap metabolic acidosis. Fomepizole inhibits alcohol dehydrogenase and prevents generation of the toxic metabolite. Ver explicação completa e trilha adaptativa →