A 63-year-old male coal miner with 40-year smoking history presents with chronic productive cough and exertional dyspnea. Vital signs: BP 142/88, HR 94, RR 22, SpO2 88% on room air. Chest X-ray reveals multiple small upper lobe nodules with background emphysematous changes. FEV1/FVC ratio is 0.58. He denies hemoptysis. Currently on albuterol inhaler only. Which of the following best describes the pathogenesis of his disease?
- A)Mutation in BMPR2 causing pulmonary arterial remodeling
- B)Aspiration of anaerobes causing cavitary necrosis
- C)IgE mediated reaction to colonizing fungi in central bronchi
- D)Loss of surfactant due to premature birth
- E)Carbon laden macrophages trigger chronic inflammatory fibrosisGABARITO
Explicação
Carbon laden macrophages trigger chronic inflammatory fibrosis is correct. Coal workers pneumoconiosis results from inhaled coal dust that is taken up by macrophages, producing anthracotic pigmentation and, in more severe cases, progressive massive fibrosis. M... Ver explicação completa e trilha adaptativa →